Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction

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Role of pulmonary function in the detection of allograft dysfunction after heart-lung transplantation.

BACKGROUND Lung function is altered by infection and rejection in patients who undergo heart-lung transplantation. The sensitivity, specificity, and positive/negative predictive values (PPV and NPV) of lung function for the detection of allograft dysfunction in these patients were measured. METHODS Thirty three patients who underwent heart-lung transplantation were followed for a mean period ...

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The prognostic importance of CXCR3 chemokine during organizing pneumonia on the risk of chronic lung allograft dysfunction after lung transplantation

RATIONALE Since the pathogenesis of chronic lung allograft dysfunction (CLAD) remains poorly defined with no known effective therapies, the identification and study of key events which increase CLAD risk is a critical step towards improving outcomes. We hypothesized that bronchoalveolar lavage fluid (BALF) CXCR3 ligand concentrations would be augmented during organizing pneumonia (OP) and that ...

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Chronic Lung Allograft Dysfunction After Lung Transplantation and Late Onset Non-infectious Pulmonary Complications After Hematopoietic Stem Cell Transplantation: Are they Mirror Images?

Cite this article: Sato M (2014) Chronic Lung Allograft Dysfunction After Lung Transplantation and Late Onset Non-infectious Pulmonary Complications After Hematopoietic Stem Cell Transplantation: Are they Mirror Images? Clin Res Pulmonol 2(1): 1014. *Corresponding author Masaaki Sato, Department of Thoracic Surgery, Kyoto University Hospital, 54Kawara-chyo, Sakyo-ku, Kyotocity, Kyoto606-8507, J...

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Chronic lung allograft dysfunction: evolving practice.

PURPOSE OF REVIEW Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight t...

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Linking clinical phenotypes of chronic lung allograft dysfunction to changes in lung structure.

Chronic lung allograft dysfunction (CLAD) remains the major barrier to long-term success after lung transplantation. This report compares gross and microscopic features of lungs removed from patients receiving a redo-transplant as treatment for CLAD. Lungs donated by patients with either the bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS) phenotype of CLAD and ap...

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ژورنال

عنوان ژورنال: The Journal of Heart and Lung Transplantation

سال: 2019

ISSN: 1053-2498

DOI: 10.1016/j.healun.2018.10.006